![]() ![]() Cardiac syncope was more frequent in those who died as compared to survivors. In a multicenter, 2-year longitudinal, observational study of elderly patients hospitalized due to syncope, total mortality was 17.2% and syncope recurrence was 32.5% ( 33). Cardiovascular complications, including arrhythmiasĭevelopment of torsades de pointes due to Q-T interval prolongation is life-threatening.Ischemic stroke due to decreased blood flow to the brain.Complications of syncope include the following: However, in patients with drug-induced cardiotoxicity leading to rhythm or conduction disorders or with a preexisting cardiac disease, the mortality rate is higher than in patients with noncardiac causes and in patients where no cause is found. The prognosis of patients with syncope due to a drug is excellent if the offending drug is discontinued. Tonic or clonic movements may occur during syncopal episodes. Other symptoms of cerebral hypoperfusion are light-headedness, general weakness, and visual disturbances. Dizziness is a frequent accompaniment of postural hypotension. Syncope is a manifestation of postural hypotension associated with some drugs such as antihypertensive medications. A patient may faint during injection of a medication as a vasovagal reaction and not due to any adverse effect of the medication. Syncope secondary to drug-induced cardiac arrhythmia may be less benign, and other signs and symptoms of cardiovascular disturbances may complicate the clinical state of the patient. It may be a simple vasovagal faint from which the patient recovers promptly without any residual signs or symptoms. Clinical manifestations of drug-induced syncope vary according to the mechanism involved. ![]() Syncope may present as 3 types, which can all be caused by drugs: (1) reflex (neurally mediated) syncope (2) cardiac syncope and (3) syncope due to postural hypotension ( 29). Prognosis is less favorable in patients with drug-induced cardiotoxicity leading to rhythm or conduction disorders or with a preexisting cardiac disease.Generally, the prognosis of patients with syncope due to a drug is excellent if the offending drug is discontinued. ![]()
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